Introduction to the course

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Uncontrolled proliferation: Sonic hedgehog signaling in the developing brain and brain tumors

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Wechsler-Reya, R. J., and M. P. Scott. "Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog." Neuron 22 (1999): 103-114.

Berman, D. M., et al. "Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade." Science 297 (2002): 1559-61.


Proto-oncogenes at the root of developmental disorders and cancer: the example of K-ras

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Hingorani, S. R., et al. "Preinvasive and Invasive Ductal Pancreatic Cancer and its early Detection in the Mouse." Cancer Cell 4 (2003): 437-50.

Schubbert S., et al. "Germline KRAS Mutations Cause Noonan Syndrome." Nat Genet 38 (2006): 331-6.


To live or to die: the general principles of apoptosis

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Ellis, H. M., and H. R. Horvitz. "Genetic Control of Programmed Cell Death in the Nematode C. Elegans." Cell 44 (1986): 817-29.

Mathas S., et al. "c-FLIP Mediates Resistance of Hodgkin/Reed-Sternberg Cells to Death Receptor-induced Apoptosis." J Exp Med 199 (2004): 1041-52.


Liver apoptosis: the case of NF-kappaB

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Rudolph D., W. C. Yeh, A. Wakeham, B. Rudolph, D. Nallainathan, J. Potter, A. J. Elia, and T. W. Mak. "Severe Liver Degeneration and Lack of NF-kappaB Activation in NEMO/IKKgamma-deficient Mice." Genes Dev 14 (2000): 854-62.

Luedde, T., N. Beraza, V. Kotsikoris, G. van Loo, A. Nenci, R. De Vos, T. Roskams, C. Trautwein, and M. Pasparakis. "Deletion of NEMO/IKKgamma in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma." Cancer Cell 11 (2007): 119-32.


Stem cells and self-renewal

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Reya, T., A. W. Duncan, L. Ailles, J. Domen, D. C. Scherer, K. Willert, L. Hintz, R. Nusse, and I. L. Weissman. "A Role for Wnt Signaling in Self-renewal of Hematopoietic Stem Cells." Nature 423 (2003): 409-14.

Morin, P. J., A. B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K. W. Kinzler. "Activation of Beta-catenin-Tcf Signaling in Colon Cancer by Mutations in Beta-catenin or APC." Science 275 (1997): 1787-90.


Angiogenesis: the formation of new blood vessels and the role of VEGF

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Gerber, H. P., et al. "VEGF is Required for Growth and Survival in Neonatal Mice." Development 126 (1999): 1149-59.

Inoue, M., J. H. Hager, N. Ferrara, H. P. Gerber, and D. Hanahan. "VEGF-A has a Critical, Nonredundant Role in Angiogenic Switching and Pancreatic Cell Carcinogenesis." Cancer Cell 1 (2002): 193-202.


Metastasis, the lethal spread of cancer

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Leptin, M. "Twist and Snail as Positive and Negative Regulators During Drosophila Mesoderm Development." Genes Dev 5 (1991): 1568-76.

Yang, J., et al. "Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis." Cell 117 (2004): 927-39.


Metastasis part II: the case of TGF-Beta

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Bardeesy, N., et al. "Smad4 is Dispensable for Normal Pancreas Development yet Critical in Progression and Tumor Biology of Pancreas Cancer." Genes Dev 20 (2006): 3130-46.

Cui, W., D. J. Fowlis, S. Bryson, E. Duffie, H. Ireland, A. Balmain, and R. J. Akhurst. "TGFbeta1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice." Cell 86 (1996): 531-42.


Growth factor signaling: from normal function to clinical treatment

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Miettinen, P. J., J. E. Berger, J. Meneses, Y. Phung, R. A. Pedersen, Z. Werb, and R. Derynck. "Epithelial Immaturity and Multiorgan Failure in Mice Lacking Epidermal Growth Factor Receptor." Nature 376 (1995): 337-41.

Lynch, T. J., et al. "Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Nonsmall-cell Lung Cancer to Gefitinib." N Engl J Med 350 (2004): 2129-39.


MicroRNAs in development and cancer

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Ventura, A., et al. "Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17 through 92 Family of miRNA Clusters." Cell 132 (2008): 875-86.

He, L., et al. "A MicroRNA Polycistron as a Potential Human Oncogene." Nature 435 (2005): 828-33.


Final class

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