| 1 |
Introduction |
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| 2 |
The Discovery of RNA Interference |
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| 3 |
The Basic Mechanism of RNAi |
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| 4 |
Physiological Relevance of the RNAi Pathway |
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| 5 |
Short-interfering RNAs (siRNAs) and their Delivery to Cells |
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| 6 |
Stable Expression of siRNA: Short Hairpins and Expression Vectors |
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| 7 |
Generation of Transgenic Animals for in vivo Silencing |
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| 8 |
Field Trip to Mouse-transgenesis Facility |
Assignment 1 due |
| 9 |
Discussion of First Written Assignment |
Choose journal article papers for second assignment |
| 10 |
Design of Potent siRNA Sequences |
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| 11 |
Large-scale Genetic Analyses Using RNAi |
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| 12 |
Student Oral Presentations of their Chosen Papers |
Assignment 2 due |
| 13 |
Using RNAi in the Prevention of Disease |
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| 14 |
Course Summary and Discussion on the Future of RNAi |
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