| 1 |
Reaction models; simple kinetics & equilibria |
Bob Sauer |
| 2 |
Analyzing kinetic & equilibria experiments |
|
| 3 |
Free energy, entropy, enthalpy & cycles |
|
| 4 |
Forces, hydrophobic effect, chelate effect |
|
| 5 |
Molecular structure and dynamics |
|
| 6 |
Physical properties of proteins and nucleic acids |
Tania Baker |
| 7 |
Principles and practice of protein purification |
|
| 8 |
Principles and practice of protein purification (cont.) |
|
| 9 |
EXAM 1 |
|
| 10 |
Domain & subunit organization; molecular weight determination |
Tania Baker |
| 11 |
Macromolecular interactions: specificity, affinity and energetics |
|
| 12 |
Macromolecular interactions: specificity, affinity and energetics (cont.) |
|
| 13 |
Enzyme catalysis: kinetics |
Frank Solomon |
| 14 |
Mechanism of enzyme catalyzed reactions |
|
| 15 |
inhibition and intermediates |
|
| 16 |
Mechanism of enzyme catalyzed reactions: chemistry |
|
| 17 |
Mechanism of enzyme catalyzed reactions: partitioning & exchange |
|
| 18 |
Mechanism of enzyme catalyzed reactions: binding energy |
|
| 19 |
Specificity of catalysis: energetics and consequences |
|
| 20 |
Specificity of catalysis: energetics and consequences (cont.) |
|
| 21 |
EXAM 2 |
|
| 22 |
Coupled vectorial processes: making ATP |
Frank Solomon |
| 23 |
Coupled vectorial processes: pumps |
|
| 24 |
Coupled vectorial processes: OxPhos, morphology to enzymology |
|
| 25 |
Coupled vectorial processes: processivity |
|
| 26 |
Coupled vectorial processes: Motors; Polymers – origins & consequences of structural & thermodynamic polarity |
|
| 27 |
Coupled vectorial processes: motors; structural & thermodynamic polarity |
|
| 28 |
Coupled vectorial processes: protein folding |
|
| 29 |
Review Session |
|
| 30 |
FINAL EXAM |
|
